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Target
E3 ubiquitin-protein ligase Mdm2 [17-125]
Ligand
BDBM326308
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
178±n/a nM
Citation
 Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent  US9637493 Publication Date 5/2/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [17-125]
Synonyms:
Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12522.24
Organism:
Homo sapiens (Human)
Description:
Residue 17 to 125
Residue:
109
Sequence:
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN
  
Inhibitor
Name:
BDBM326308
Synonyms:
4-{[(1R)-1- cyclobutylethyl]amino}- 6-(3-methylphenyl)-5- {[6- (trifluoromethyl)pyridin- 3-yl]methyl}-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid | US9637493, 3.3
Type:
Small organic molecule
Emp. Form.:
C27H26F3N5O2
Mol. Mass.:
509.5228
SMILES:
C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(nc3)C(F)(F)F)c12)C(O)=O)C1CCC1 |r|
Structure:
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