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Target
E3 ubiquitin-protein ligase Mdm2 [17-125]
Ligand
BDBM326317
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
226±n/a nM
Citation
 Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent  US9637493 Publication Date 5/2/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [17-125]
Synonyms:
Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12522.24
Organism:
Homo sapiens (Human)
Description:
Residue 17 to 125
Residue:
109
Sequence:
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN
  
Inhibitor
Name:
BDBM326317
Synonyms:
4-(3-chlorophenyl)-7- methyl-5-[(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidine-2-carboxylic acid | US9637493, 5.1
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O2
Mol. Mass.:
397.898
SMILES:
C[C@H]1CC[C@H](Cn2cc(C)c3nc(nc(-c4cccc(Cl)c4)c23)C(O)=O)CC1 |r,wU:4.4,wD:1.0,(6.07,-4.33,;4.73,-3.56,;4.73,-2.02,;3.4,-1.25,;2.07,-2.02,;.73,-1.25,;.73,.29,;1.64,1.54,;.73,2.79,;1.5,4.12,;-.73,2.31,;-2.07,3.08,;-3.4,2.31,;-3.4,.77,;-2.07,,;-2.07,-1.54,;-.73,-2.31,;-.73,-3.85,;-2.07,-4.62,;-3.4,-3.85,;-4.73,-4.62,;-3.4,-2.31,;-.73,.77,;-4.73,3.08,;-6.07,2.31,;-4.73,4.62,;2.07,-3.56,;3.4,-4.33,)|
Structure:
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