Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM326378
Substrate
n/a
Meas. Tech.
Enzyme Inhibitory Assay
IC50
26.0±n/a nM
Citation
 Nagata, T; Kobayashi, J; Onishi, Y; Kishida, M; Noguchi, K Cyclopropanecarboxylic acid derivative US Patent  US9662310 Publication Date 5/30/2017 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM326378
Synonyms:
(1R*,2S*)-2-(3-Aminopropyl)-1-[1-(1-benzofuran-5-yl)-1H-imidazol-4-yl]cyclopropanecarboxylic acid | US9662310, Example 43
Type:
Small organic molecule
Emp. Form.:
C29H37N3O7
Mol. Mass.:
539.62
SMILES:
COC(=O)C1(CC1CCCN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1cn(cn1)-c1ccc2occc2c1
Structure:
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