Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM326381
Substrate
n/a
Meas. Tech.
Enzyme Inhibitory Assay
IC50
16.0±n/a nM
Citation
 Nagata, T; Kobayashi, J; Onishi, Y; Kishida, M; Noguchi, K Cyclopropanecarboxylic acid derivative US Patent  US9662310 Publication Date 5/30/2017 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM326381
Synonyms:
(1R*,2S*)-2-(3-Aminopropyl)-1-(1-isoquinolin-3-yl-1H-imidazol-4-yl)cyclopropanecarboxylic acid | US9662310, Example 46
Type:
Small organic molecule
Emp. Form.:
C24H27N5O2
Mol. Mass.:
417.5035
SMILES:
CC(C)(C)OC(=O)NCCCC1CC1(C#N)c1cn(cn1)-c1cc2ccccc2cn1
Structure:
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