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Target
Ribosomal protein S6 kinase beta-1
Ligand
BDBM224463
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
1000±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent  US9662330 Publication Date 5/30/2017 
Target
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM224463
Synonyms:
US10080750, Compound 141 | US9321760, 141 | US9662330, Compound 141
Type:
Small organic molecule
Emp. Form.:
C18H21FN4O
Mol. Mass.:
328.3839
SMILES:
Nc1ncnc(N2CCC(CC2)C(O)c2ccc(F)cc2)c1C=C
Structure:
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