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TargetLeukotriene A4 hydrolase
LigandBDBM327182
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50 0.160±n/a nM
Citation Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent US9662339 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A4 hydrolase
Name:Leukotriene A4 hydrolase
Synonyms:LTA-4 hydrolase | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H)
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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  Blast E-value cutoff:
BDBM327182
NameBDBM327182
Synonyms:4-{1-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin-3-yl)- benzyl]-piperidin-4-yl]- cyclohexanecarboxylic acid | US9662339, 265
TypeSmall organic molecule
Emp. Form.C26H32N2O4
Mol. Mass.436.5433
SMILESOC(=O)C1CCC(CC1)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r,wU:20.21,(10.67,-1.15,;9.34,-1.93,;9.34,-3.47,;8,-1.15,;6.67,-1.93,;5.33,-1.15,;5.33,.38,;6.67,1.15,;8,.38,;4,1.15,;2.67,.38,;1.33,1.15,;1.33,2.69,;,3.47,;-1.33,2.69,;-1.33,1.15,;-2.67,.38,;-4,1.15,;-4,2.69,;-2.67,3.46,;-5.33,.38,;-5.33,-1.16,;-6.67,-1.93,;-8,-1.16,;-9.34,-1.93,;-10.67,-1.16,;-10.67,.38,;-9.34,1.15,;-8,.38,;-6.67,1.15,;2.67,3.47,;4,2.69,)|
Structure
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