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TargetC-C chemokine receptor type 2
LigandBDBM327352
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 77.0±n/a nM
Citation Yuan, HBeard, RLGarst, MEDonello, JELiu, XViswanath, V Sulfur derivatives as chemokine receptor modulators US Patent US9663460 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C chemokine receptor type 2 (CCR2) | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:Enzyme
Mol. Mass.:41932.32
Organism:Homo sapiens (Human)
Description:P41597
Residue:374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM327352
NameBDBM327352
Synonyms:N-{5-chloro-2-[(3-hydroxybenzyl)thio]phenyl}-1-benzofuran-2-sulfonamide | US9663460, Example 158
TypeSmall organic molecule
Emp. Form.C21H16ClNO4S2
Mol. Mass.445.939
SMILESOc1cccc(CSc2ccc(Cl)cc2NS(=O)(=O)c2cc3ccccc3o2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a