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TargetC-C chemokine receptor type 2
LigandBDBM327374
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 79.0±n/a nM
Citation Yuan, HBeard, RLGarst, MEDonello, JELiu, XViswanath, V Sulfur derivatives as chemokine receptor modulators US Patent US9663460 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C chemokine receptor type 2 (CCR2) | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:Enzyme
Mol. Mass.:41932.32
Organism:Homo sapiens (Human)
Description:P41597
Residue:374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Blast this sequence in BindingDB or PDB
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BDBM327374
NameBDBM327374
Synonyms:N-(5-chloro-2-{[(2-fluoropyridin-3-yl)methyl]-sulfonyl}phenyl)-1-benzofuran-2-sulfonamide | US9663460, Example 181
TypeSmall organic molecule
Emp. Form.C20H14ClFN2O5S2
Mol. Mass.480.917
SMILESFc1ncccc1CS(=O)(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cc2ccccc2o1
Structure
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