Target
Collagenase ColG
Ligand
BDBM11733
Substrate
BDBM11462
Meas. Tech.
ChC Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
18000±n/a nM
Citation
 Scozzafava, ASupuran, CT Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties. Bioorg Med Chem 8:637-45 (2000) [PubMed]  Article 
Target
Name:
Collagenase ColG
Synonyms:
3.4.24.3 | COLG_HATHI | Class I collagenase | Collagenase (ChC) | Collagenase ColG | Gelatinase ColG | Microbial collagenase | class 1 collagenase | colG
Type:
Enzyme
Mol. Mass.:
126246.16
Organism:
Clostridium histolyticum
Description:
Q9S0X0
Residue:
1118
Sequence:
MKKNILKILMDSYSKESKIQTVRRVTSVSLLAVYLTMNTSSLVLAKPIENTNDTSIKNVEKLRNAPNEENSKKVEDSKNDKVEHVKNIEEAKVEQVAPEVKSKSTLRSASIANTNSEKYDFEYLNGLSYTELTNLIKNIKWNQINGLFNYSTGSQKFFGDKNRVQAIINALQESGRTYTANDMKGIETFTEVLRAGFYLGYYNDGLSYLNDRNFQDKCIPAMIAIQKNPNFKLGTAVQDEVITSLGKLIGNASANAEVVNNCVPVLKQFRENLNQYAPDYVKGTAVNELIKGIEFDFSGAAYEKDVKTMPWYGKIDPFINELKALGLYGNITSATEWASDVGIYYLSKFGLYSTNRNDIVQSLEKAVDMYKYGKIAFVAMERITWDYDGIGSNGKKVDHDKFLDDAEKHYLPKTYTFDNGTFIIRAGDKVSEEKIKRLYWASREVKSQFHRVVGNDKALEVGNADDVLTMKIFNSPEEYKFNTNINGVSTDNGGLYIEPRGTFYTYERTPQQSIFSLEELFRHEYTHYLQARYLVDGLWGQGPFYEKNRLTWFDEGTAEFFAGSTRTSGVLPRKSILGYLAKDKVDHRYSLKKTLNSGYDDSDWMFYNYGFAVAHYLYEKDMPTFIKMNKAILNTDVKSYDEIIKKLSDDANKNTEYQNHIQELADKYQGAGIPLVSDDYLKDHGYKKASEVYSEISKAASLTNTSVTAEKSQYFNTFTLRGTYTGETSKGEFKDWDEMSKKLDGTLESLAKNSWSGYKTLTAYFTNYRVTSDNKVQYDVVFHGVLTDNADISNNKAPIAKVTGPSTGAVGRNIEFSGKDSKDEDGKIVSYDWDFGDGATSRGKNSVHAYKKAGTYNVTLKVTDDKGATATESFTIEIKNEDTTTPITKEMEPNDDIKEANGPIVEGVTVKGDLNGSDDADTFYFDVKEDGDVTIELPYSGSSNFTWLVYKEGDDQNHIASGIDKNNSKVGTFKSTKGRHYVFIYKHDSASNISYSLNIKGLGNEKLKEKENNDSSDKATVIPNFNTTMQGSLLGDDSRDYYSFEVKEEGEVNIELDKKDEFGVTWTLHPESNINDRITYGQVDGNKVSNKVKLRPGKYYLLVYKYSGSGNYELRVNK
  
Inhibitor
Name:
BDBM11733
Synonyms:
2-{[(2-chlorophenyl)methyl](4-methylbenzene)sulfonamido}propanoic acid | Carboxylic acid deriv. A13
Type:
Small organic molecule
Emp. Form.:
C17H18ClNO4S
Mol. Mass.:
367.847
SMILES:
CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(C)cc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM11462
Synonyms:
Collagenase Substrate | FALGPA | furanacryloyl-leucyl-glycyl-prolyl-alanine
Type:
n/a
Emp. Form.:
C23H32N4O7
Mol. Mass.:
476.5228
SMILES:
CC(C)C[C@H](NC(=O)\C=C\c1ccco1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Structure:
Search PDB for entries with ligand similarity: