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TargetLysine-specific histone demethylase 1A
LigandBDBM194641
Substrate/Competitorn/a
Meas. Tech.LSD1 Histone Demethylase Biochemical Assay
pH7.5±n/a
IC50<100±n/a nM
Commentsextracted
Citation Wu, LHe, CYao, WZhang, F Cyclopropylamines as LSD1 inhibitors US Patent US9670210 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific histone demethylase 1A
Name:Lysine-specific histone demethylase 1A
Synonyms:AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:Enzyme
Mol. Mass.:92901.01
Organism:Homo sapiens (Human)
Description:O60341
Residue:852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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  Blast E-value cutoff:
BDBM194641
NameBDBM194641
Synonyms:US10174030, Example 58 | US9670210, Example 58 trans-4-{[4-(3-cyanobenzyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}cyclohexanecarboxylic acid
TypeSmall organic molecule
Emp. Form.C31H39N3O2
Mol. Mass.485.6603
SMILESOC(=O)[C@H]1CC[C@H](CN2CCC(CN[C@@H]3CC3c3ccccc3)(Cc3cccc(c3)C#N)CC2)CC1 |r,wU:14.13,3.2,wD:6.6,(8.82,.36,;8.82,1.9,;10.15,2.67,;7.49,2.67,;6.1,1.92,;4.77,2.7,;4.77,4.23,;3.44,5,;2.1,4.23,;2.1,2.69,;.77,1.92,;-.56,2.69,;-1.9,1.92,;-3.23,2.69,;-4.56,1.92,;-5.33,3.26,;-6.1,1.92,;-7.44,1.15,;-8.77,1.92,;-10.11,1.15,;-10.11,-.39,;-8.77,-1.16,;-7.44,-.39,;-.56,1.15,;.77,.38,;2.1,1.15,;3.44,.38,;3.44,-1.16,;2.1,-1.98,;.77,-1.16,;2.1,-3.52,;2.1,-5.06,;-.56,4.23,;.77,5,;6.1,5.01,;7.44,4.23,)|
Structure
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