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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM194714
Substrate
n/a
Meas. Tech.
LSD1 Histone Demethylase Biochemical Assay
pH
7.5±n/a
IC50
<100±n/a nM
Comments
extracted
Citation
 Wu, L; He, C; Yao, W; Zhang, F Cyclopropylamines as LSD1 inhibitors US Patent  US9670210 Publication Date 6/6/2017 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM194714
Synonyms:
US10174030, Example 100 | US10717737, Example 100 | US11247992, Example 100 | US9670210, Example 100 (trans-4-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]carbonyl}cyclohexyl)methanol
Type:
Small organic molecule
Emp. Form.:
C25H38N2O3
Mol. Mass.:
414.5808
SMILES:
COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)[C@H]1CC[C@H](CO)CC1 |r,wU:6.5,22.24,wD:25.28,(-.63,-4.07,;-.1,-2.63,;-1.09,-1.45,;-.56,,;-1.9,-.77,;-3.23,,;-4.56,-.77,;-5.33,.56,;-6.1,-.77,;-7.44,-1.54,;-8.77,-.77,;-10.11,-1.54,;-10.11,-3.08,;-8.77,-3.85,;-7.44,-3.08,;.77,-.77,;2.1,,;2.1,1.54,;.77,2.31,;-.56,1.54,;3.44,2.31,;3.44,3.85,;4.77,1.54,;6.1,2.31,;7.44,1.54,;7.44,,;8.77,-.77,;10.11,,;6.1,-.77,;4.77,,)|
Structure:
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