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TargetLysine-specific histone demethylase 1A
LigandBDBM194715
Substrate/Competitorn/a
Meas. Tech.LSD1 Histone Demethylase Biochemical Assay
pH7.5±n/a
IC50<100±n/a nM
Commentsextracted
Citation Wu, LHe, CYao, WZhang, F Cyclopropylamines as LSD1 inhibitors US Patent US9670210 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific histone demethylase 1A
Name:Lysine-specific histone demethylase 1A
Synonyms:AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:Enzyme
Mol. Mass.:92901.01
Organism:Homo sapiens (Human)
Description:O60341
Residue:852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM194715
NameBDBM194715
Synonyms:US10174030, Example 101 | US9670210, Example 101 (cis-4-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]carbonyl}cyclohexyl)methanol
TypeSmall organic molecule
Emp. Form.C25H38N2O3
Mol. Mass.414.5808
SMILESCOCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)[C@@H]1CC[C@H](CO)CC1 |r,wU:6.5,22.24,25.28,(-.63,-4.07,;-.1,-2.63,;-1.09,-1.45,;-.56,,;-1.9,-.77,;-3.23,,;-4.56,-.77,;-5.33,.56,;-6.1,-.77,;-7.44,-1.54,;-8.77,-.77,;-10.11,-1.54,;-10.11,-3.08,;-8.77,-3.85,;-7.44,-3.08,;.77,-.77,;2.1,,;2.1,1.54,;.77,2.31,;-.56,1.54,;3.44,2.31,;3.44,3.85,;4.77,1.54,;4.77,,;6.1,-.77,;7.44,,;8.77,-.77,;10.11,,;7.44,1.54,;6.1,2.31,)|
Structure
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