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Target
Cathepsin D
Ligand
BDBM327793
Substrate
n/a
Meas. Tech.
IN-VITRO FLUORESCENCE ASSAY
IC50
780±n/a nM
Citation
 Klein, M; Tsaklakidis, C 2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors US Patent  US9663475 Publication Date 5/30/2017 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM327793
Synonyms:
US9663475, Compound A11
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3O2
Mol. Mass.:
357.834
SMILES:
COc1ccc2CC(Cc2c1OC)N1Cc2ccc(Cl)cc2N=C1N |c:25|
Structure:
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