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Target
Cathepsin D
Ligand
BDBM327803
Substrate
n/a
Meas. Tech.
IN-VITRO FLUORESCENCE ASSAY
IC50
270±n/a nM
Citation
 Klein, M; Tsaklakidis, C 2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors US Patent  US9663475 Publication Date 5/30/2017 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM327803
Synonyms:
US9663475, Compound A18
Type:
Small organic molecule
Emp. Form.:
C19H18F3N3O
Mol. Mass.:
361.3609
SMILES:
COc1ccc2C[C@@H](Cc2c1)N1Cc2ccc(cc2N=C1N)C(F)(F)F |r,c:22|
Structure:
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