Target

Ligand

Substrate

Meas. Tech.

PKB In Vitro Kinase Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Breitenlechner, CB; Wegge, T; Berillon, L; Graul, K; Marzenell, K; Friebe, WG; Thomas, U; Schumacher, R; Huber, R; Engh, RA; Masjost, B Structure-based optimization of novel azepane derivatives as PKB inhibitors. J Med Chem 47:1375-90 (2004) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11826

Synonyms:

Azepane Derivative 7 | N-((3R,4R)-4-{[4-(2-fluoro-6-hydroxy-3-methoxybenzoyl)benzyl]amino}azepan-3-yl)isonicotinamide trihydrochloride | N-[(3R,4R)-4-[({4-[(2-fluoro-6-hydroxy-3-methoxyphenyl)carbonyl]phenyl}methyl)amino]azepan-3-yl]pyridine-4-carboxamide trihydrochloride

Type:

Small organic molecule

Emp. Form.:

C27H29FN4O4

Mol. Mass.:

492.542

SMILES:

COc1ccc(O)c(C(=O)c2ccc(CN[C@@H]3CCCNC[C@H]3NC(=O)c3ccncc3)cc2)c1F |r|

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Biotinylated Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

1764.91

Organism:

n/a

Description:

n/a

Residue:

17

Sequence:

ITINSGRARTSSFAEPG