Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM327834
Substrate
n/a
Meas. Tech.
Cell-Based Assay
IC50
7.20±n/a nM
Citation
 Hitchcock, SA; Amegadzie, A; Qian, W; Xia, X; Harried, SS Glycine transporter-1 inhibitors US Patent  US9663476 Publication Date 5/30/2017 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM327834
Synonyms:
US9663476, Compound 30 | [(R)-4-((R)-biphenyl-3-yl-phenyl-methyl)-2-methyl-piperazin-1-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H28N2O2
Mol. Mass.:
400.5127
SMILES:
C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1cccc(c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: