Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM327910
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
<500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM327910
Synonyms:
N-(1-(4- chlorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide | US10377742, Compound 51 | US9663496, Compound 51
Type:
Small organic molecule
Emp. Form.:
C32H37FN4O3
Mol. Mass.:
544.6596
SMILES:
COc1ccc(CC2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1 |(14.67,1.15,;13.34,.38,;12,1.15,;10.67,.38,;9.34,1.15,;9.34,2.69,;8,3.47,;6.67,2.69,;6.67,1.15,;5.33,.38,;4,1.15,;4,2.69,;5.33,3.47,;2.67,.38,;1.33,1.15,;1.33,2.69,;,.38,;-1.33,1.15,;-2.67,.38,;-2.67,-1.15,;-1.33,-1.93,;,-1.15,;-4,-1.93,;-4,-3.47,;-5.33,-1.15,;-5.33,.38,;-6.67,1.15,;-8,.38,;-9.34,1.15,;-10.67,.38,;-12,1.15,;-13.34,.38,;-13.34,-1.15,;-14.67,-1.93,;-12,-1.93,;-10.67,-1.15,;-8,-1.15,;-6.67,-1.93,;10.67,3.47,;12,2.69,)|
Structure:
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