Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM327962
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
7500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM327962
Synonyms:
N-(4-(4-cyanobenzyl) cyclohexyl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide | US10377742, Compound 99 | US9663496, Compound 99
Type:
Small organic molecule
Emp. Form.:
C32H34FN5O2
Mol. Mass.:
539.6431
SMILES:
Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)NC2CCC(Cc3ccc(cc3)C#N)CC2)cc1 |(-14.67,-.38,;-13.34,.38,;-12,-.38,;-10.67,.38,;-10.67,1.93,;-9.34,2.69,;-8,1.93,;-6.67,2.69,;-5.33,1.93,;-5.33,.38,;-6.67,-.38,;-8,.38,;-4,-.38,;-4,-1.93,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;,.38,;-1.33,-.38,;1.33,-.38,;1.33,-1.93,;2.67,.38,;4,-.38,;4,-1.93,;5.33,-2.69,;6.67,-1.93,;8,-2.69,;9.34,-1.93,;10.67,-2.69,;12,-1.93,;12.05,-.36,;10.67,.38,;9.34,-.38,;13.39,.41,;14.72,1.18,;6.67,-.38,;5.33,.38,;-12,2.69,;-13.34,1.93,)|
Structure:
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