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TargetSerotonin (5-HT) receptor
LigandBDBM328397
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 0.090±n/a nM
Citation Zhang, YJin, CZhong, WZhang, JGao, LChen, K Aromatic heterocyclic compounds and their application in pharmaceuticals US Patent US9663498 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
Serotonin (5-HT) receptor
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM328397
NameBDBM328397
Synonyms:6-chloro-3-(difluoromethyl)-1-((3-(4-isopropylpiperazin-1-yl)-4-methoxyphenyl)sulfonyl)-1H-indole | US9663498, Example 40
TypeSmall organic molecule
Emp. Form.C23H26ClF2N3O3S
Mol. Mass.497.986
SMILESCOc1ccc(cc1N1CCN(CC1)C(C)C)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12
Structure
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