Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM328401
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
0.250±n/a nM
Citation
 Zhang, Y; Jin, C; Zhong, W; Zhang, J; Gao, L; Chen, K Aromatic heterocyclic compounds and their application in pharmaceuticals US Patent  US9663498 Publication Date 5/30/2017 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM328401
Synonyms:
3-(difluoromethyl)-1-((3-(4-ethylpiperazin-1-yl)-4-methoxyphenyl) sulfonyl)-6-(trifluoromethyl)-1H-indole | US9663498, Example 46
Type:
Small organic molecule
Emp. Form.:
C23H24F5N3O3S
Mol. Mass.:
517.512
SMILES:
CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F
Structure:
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