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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM329387
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay
IC50
>120±n/a nM
Citation
 Swenson, RE Sphingosine 1-phosphate receptor antagonists US Patent  US9663511 Publication Date 5/30/2017 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM329387
Synonyms:
US9663511, Compound 44.
Type:
Small organic molecule
Emp. Form.:
C21H24ClF3N6O2
Mol. Mass.:
484.902
SMILES:
CC(C)c1cc(nc2n(C)nc(C)c12)N(CCO)NC(=O)Nc1cc(Cl)cc(c1)C(F)(F)F
Structure:
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