Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329820
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
<10±n/a nM
Citation
 Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017 
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
  
Inhibitor
Name:
BDBM329820
Synonyms:
(rac)-((1R,2R,3S,4R)-4-((2-(3-Bromophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)- | US10202389, Compound I-028 | US9663525, Compound I-028 | US9796725, Compound I-028
Type:
Small organic molecule
Emp. Form.:
C18H20BrN5O5S
Mol. Mass.:
498.351
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(Br)c2)[C@H](O)[C@@H]1O |r|
Structure:
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