Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329903
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
<10±n/a nM
Citation
 Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017 
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
  
Inhibitor
Name:
BDBM329903
Synonyms:
(s.e.)-((1R,2R,3S,4R)-4-(2-(6-(difluoromethyl)naphthalen-1-yl)pyrazolo[1,5- | US10202389, Compound I-111 | US9663525, Compound I-111 | US9796725, Compound I-111
Type:
Small organic molecule
Emp. Form.:
C23H23F2N5O5S
Mol. Mass.:
519.521
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc3cc(ccc23)C(F)F)[C@H](O)[C@@H]1O |r|
Structure:
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