Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329905
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
<10±n/a nM
Citation
 Afroze, RBharathan, ITCiavarri, JPFleming, PEGaulin, JLGirard, MLangston, SPSoucy, FWong, TYe, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017 
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
  
Inhibitor
Name:
BDBM329905
Synonyms:
(s.e.)-((1R,2R,3S,4R)-4-(2-(6-fluoronaphthalen-2-yl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-113 | US9663525, Compound I-113 | US9796725, Compound I-113
Type:
Small organic molecule
Emp. Form.:
C22H22FN5O5S
Mol. Mass.:
487.504
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2ccc3cc(F)ccc3c2)[C@H](O)[C@@H]1O |r|
Structure:
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