Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329917
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
550±n/a nM
Citation
 Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017 
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
  
Inhibitor
Name:
BDBM329917
Synonyms:
(s.e.)-{(1R,2R,3S,4R)-4-[(6-chloro-2-{3-[(trifluoromethyl)sulfanyl]phenyl}pyrazolo[1, | US10202389, Compound I-125 | US9663525, Compound I-125 | US9796725, Compound I-125
Type:
Small organic molecule
Emp. Form.:
C19H19ClF3N5O5S2
Mol. Mass.:
553.963
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2c(Cl)cnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O |r|
Structure:
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