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Target
Tyrosine-protein kinase Blk
Ligand
BDBM195886
Substrate
n/a
Meas. Tech.
EGFR kinase assay
Temperature
298.15±n/a K
IC50
812±n/a nM
Comments
extracted
Citation
 Li, H; Xu, Y; Zhao, Z; Liu, X; Zhou, W; Bai, F; Xue, M; Zhang, L; Zhang, Y Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor US Patent  US9670213 Publication Date 6/6/2017 
Target
Name:
Tyrosine-protein kinase Blk
Synonyms:
B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk
Type:
Protein
Mol. Mass.:
57711.88
Organism:
Homo sapiens (Human)
Description:
P51451
Residue:
505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
  
Inhibitor
Name:
BDBM195886
Synonyms:
US9670213, Compound 031 N-(4-(2-(2-methoxy)-4-(4-methoxy-1-piperazinyl)-phenylamino)-7-oxo-8(7H)-pteridinyl)phenyl)acrylamide
Type:
Small organic molecule
Emp. Form.:
C27H28N8O3
Mol. Mass.:
512.563
SMILES:
COc1cc(ccc1Nc1ncc2ncc(=O)n(-c3ccc(NC(=O)C=C)cc3)c2n1)N1CCN(C)CC1
Structure:
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