Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM330193
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Mouse
IC50
1437±n/a nM
Citation
 Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives US Patent  US9663530 Publication Date 5/30/2017 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM330193
Synonyms:
(RS)—N-[4-(5-Oxa-2-azabicyclo[2.2.2]octan-4-yl)phenyl]-2-(trifluoromethyl)pyridine-4-carboxamide | US9663530, Example 37
Type:
Small organic molecule
Emp. Form.:
C19H18F3N3O2
Mol. Mass.:
377.3603
SMILES:
FC(F)(F)c1cc(ccn1)C(=O)Nc1ccc(cc1)C12CCC(CO1)NC2
Structure:
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