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Target
Caspase-1
Ligand
BDBM12070
Substrate
Caspase-1 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
Ki
290±n/a nM
Citation
 Shahripour, AB; Plummer, MS; Lunney, EA; Sawyer, TK; Stankovic, CJ; Connolly, MK; Rubin, JR; Walker, NP; Brady, KD; Allen, HJ; Talanian, RV; Wong, WW; Humblet, C Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide. Bioorg Med Chem Lett 11:2779-82 (2001) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM12070
Synonyms:
(3S)-4-oxo-3-{[2-(4-phenylphenoxy)benzene]sulfonamido}butanoic acid | Diphenyl Ether Sulfonamide 16
Type:
Small organic molecule
Emp. Form.:
C22H19NO6S
Mol. Mass.:
425.454
SMILES:
OC(=O)C[C@H](NS(=O)(=O)c1ccccc1Oc1ccc(cc1)-c1ccccc1)C=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-1 Fluorogenic Substrate
Synonyms:
Ac-YVAD-AMC
Type:
n/a
Mol. Mass.:
1713.07
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
17
Sequence:
ACTYRVALALAASPAMC