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Target
Eyes absent homolog 3
Ligand
BDBM330353
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
41900±n/a nM
Citation
 Hegde, R Use of small molecule inhibitors targeting EYA tyrosine phosphatase US Patent  US9725430 Publication Date 8/8/2017 
Target
Name:
Eyes absent homolog 3
Synonyms:
EYA3 | EYA3_HUMAN | Eyes absent homolog 3 (EYA3)
Type:
Protein
Mol. Mass.:
62648.48
Organism:
Homo sapiens (Human)
Description:
Q99504
Residue:
573
Sequence:
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
  
Inhibitor
Name:
BDBM330353
Synonyms:
US9725430, Compound 1i | US9962362, Compound 1i
Type:
Small organic molecule
Emp. Form.:
C17H12Br2O4
Mol. Mass.:
440.083
SMILES:
CC(O)c1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
Structure:
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