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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM196174
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human 51P5 Receptors
EC50
6.30±n/a nM
Citation
 Smid, P; Iwema Bakker, WI; Coolen, HK; Sliedregt, LA; van Dongen, MJ; den Hartog, JA; Hobson, A Fused heterocyclic derivatives as S1P modulators US Patent  US9670220 Publication Date 6/6/2017 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM196174
Synonyms:
US9670220, 89
Type:
Small organic molecule
Emp. Form.:
C24H25FN2O4
Mol. Mass.:
424.4647
SMILES:
Cc1cc(ccc1OCc1ccccc1F)-c1nc2CN(CCCC(O)=O)CCc2o1
Structure:
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