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TargetCytochrome P450 11A1 (CYP11A1)
LigandBDBM330383
Substrate/Competitorn/a
Meas. Tech.Cyp11 Assay
IC50 200±n/a nM
Citation Blass, BEAbou-Gharbia, MAChilders, WEIyer, PBoruwa, J Cytochrome P450 inhibitors and their method of use US Patent US9725436 Publication Date 8/8/2017
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11A1 (CYP11A1)
Name:Cytochrome P450 11A1 (CYP11A1)
Synonyms:CYPXIA1 | Cholesterol desmolase | Cholesterol side-chain cleavage enzyme, mitochondrial | Cytochrome P450 11A1 | P450(scc)
Type:Protein
Mol. Mass.:60346.75
Organism:Bos taurus (Bovine)
Description:P00189
Residue:520
Sequence:
MLARGLPLRSALVKACPPILSTVGEGWGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWL
NLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPER
YDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVS
LLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKM
FHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGI
LYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR
QAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYA
MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE
NFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA
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  Blast E-value cutoff:
BDBM330383
NameBDBM330383
Synonyms:US9725436, Entry 3
TypeSmall organic molecule
Emp. Form.C24H24FN3O2S
Mol. Mass.437.53
SMILESCS(=O)(=O)N1CCN(CC1)c1ccc(\C=C\c2cc(F)cc(c2)-c2ccncc2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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