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TargetCytochrome P450-C17 (CYP17A1)
LigandBDBM330397
Substrate/Competitorn/a
Meas. Tech.Cyp17 Assay
IC50 86.0±n/a nM
Citation Blass, BEAbou-Gharbia, MAChilders, WEIyer, PBoruwa, J Cytochrome P450 inhibitors and their method of use US Patent US9725436 Publication Date 8/8/2017
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450-C17 (CYP17A1)
Name:Cytochrome P450-C17 (CYP17A1)
Synonyms:Cytochrome P450 21 (CYP21)
Type:Protein
Mol. Mass.:57256.42
Organism:Bos taurus (Bovine)
Description:P05185
Residue:509
Sequence:
MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN
ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA
SLVLQIKPFKVKIEVRQAWKEAQAEGSTP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM330397
NameBDBM330397
Synonyms:US9725436, Entry 16
TypeSmall organic molecule
Emp. Form.C24H24FN5O2S
Mol. Mass.465.543
SMILESFc1cc(Cn2ccnc2)cc(\C=C\c2ccc(cc2)N2CCN(CC2)S(=O)(=O)C[N+]#[C-])c1
Structure
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n/a