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TargetDipeptidyl peptidase 2 (DPP II)
LigandBDBM12179
Substrate/CompetitorBDBM11526
Meas. Tech.Enzyme Inhibition Assay
IC50>20000±n/a nM
Citation Tsai, TYCoumar, MSHsu, THsieh, HPChien, CHChen, CTChang, CNLo, YKWu, SHHuang, CYHuang, YWWang, MHWu, HYLee, HJChen, XChao, YSJiaang, WT Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett16:3268-72 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dipeptidyl peptidase 2 (DPP II)
Name:Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4)
Synonyms:DAP II | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:Protein
Mol. Mass.:54339.29
Organism:Homo sapiens (Human)
Description:Q9UHL4
Residue:492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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  Blast E-value cutoff:
BDBM12179
NameBDBM12179
Synonyms:(2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylcarbonyl)-5,5-dimethylpyrrolidin-2-yl]carbonyl}pyrrolidine-2-carbonitrile | pyrrolidine-2,4-dicarboxylic acid amide 11b
TypeSmall organic molecule
Emp. Form.C21H26N4O2
Mol. Mass.366.4567
SMILESCC1(C)N[C@@H](C[C@@H]1C(=O)N1Cc2ccccc2C1)C(=O)N1CCC[C@H]1C#N |r|
Structure
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BDBM11526
NameBDBM11526
Synonyms:1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide | Gly-Pro-p-nitroaniline | Gly-Pro-pNA
TypeSmall organic molecule
Emp. Form.C13H16N4O4
Mol. Mass.292.2905
SMILESNCC(=O)N1CCCC1C(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure
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