Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM330484
Substrate
n/a
Meas. Tech.
Receptor Binding Inhibition Assay
Ki
10.00±n/a nM
Citation
 Hata, K; Masuda, M; Nakai, H; Taniyama, D; Tobinaga, H; Hato, Y; Fujiu, M Heterocyclic derivative having PGD2 receptor antagonist activity US Patent  US9725442 Publication Date 8/8/2017 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM330484
Synonyms:
US9725442, Compound I-282
Type:
Small organic molecule
Emp. Form.:
C26H27N3O6S
Mol. Mass.:
509.574
SMILES:
CCOc1ccc(cc1)S(=O)(=O)N1C[C@@H](C)[C@H](C1)n1cc(CC(O)=O)c2ccc(cc12)-c1ncco1 |r|
Structure:
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