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TargetTyrosine-protein kinase JAK1
LigandBDBM331132
Substrate/Competitorn/a
Meas. Tech.Biochemical HTRF Assay Protocol
IC50 69.0±n/a nM
Citation Childers, MLDinsmore, CFuller, PGuerin, DKatz, JDPu, QScott, METhompson, CFZhang, HFalcone, DTorres, LBrubaker, JZeng, HCai, JDu, XWang, CBai, YKong, NLiu, YZheng, Z Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors US Patent US9725445 Publication Date 8/8/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1
Name:Tyrosine-protein kinase JAK1
Synonyms:JAK-1 | JAK1 | JAK1A | JAK1B | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1
Type:Protein
Mol. Mass.:133293.73
Organism:Homo sapiens (Human)
Description:P23458
Residue:1154
Sequence:
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
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  Blast E-value cutoff:
BDBM331132
NameBDBM331132
Synonyms:US9725445, 16-2
TypeSmall organic molecule
Emp. Form.C27H30N6O5S
Mol. Mass.550.629
SMILESOC(=O)[C@@H]1CC[C@@H](CC1)N1Cc2cc(Nc3nn([C@H]4CCCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O |r,wU:18.18,6.9,3.2,wD:23.25,(5.58,-6.67,;4.09,-7.07,;3.69,-8.56,;3,-5.98,;3.4,-4.49,;2.31,-3.4,;.82,-3.8,;.43,-5.29,;1.51,-6.38,;-.26,-2.71,;-.02,-1.19,;-1.4,-.49,;-1.79,.99,;-3.28,1.39,;-3.68,2.88,;-2.59,3.97,;-1.06,3.81,;-.43,5.22,;1.05,5.61,;1.45,7.1,;2.94,7.5,;4.03,6.41,;3.63,4.92,;2.14,4.53,;1.74,3.04,;1.35,1.55,;-1.58,6.25,;-1.58,7.79,;-2.91,8.56,;-4.25,7.79,;-4.25,6.25,;-5.58,5.48,;-2.91,5.48,;-4.37,.3,;-3.97,-1.18,;-2.48,-1.58,;-1.79,-2.95,;-2.18,-4.44,;-3.27,-3.35,)|
Structure
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