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Target
Cathepsin K
Ligand
BDBM331569
Substrate
n/a
Meas. Tech.
Enzyme Assay
Ki
16.0±n/a nM
Citation
 Nardi, A; Ratcliffe, P; Craan, T; Hertrampf, T; Lesch, B; Kime, R; Steinhagen, H 3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I US Patent  US9725459 Publication Date 8/8/2017 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM331569
Synonyms:
N-((S)-2-((3aS,6S,6aS)-6-chloro-3- oxotetrahydro-2H-furo[3,2-b]pyrrol-4(5H)-yl)- 1-cyclohexyl-2-oxoethyl)-5-(6- methoxypyridazin-3-yl)thiophene-2- carboxamide | US9725459, 34
Type:
Small organic molecule
Emp. Form.:
C24H27ClN4O5S
Mol. Mass.:
519.013
SMILES:
COc1ccc(nn1)-c1ccc(s1)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@@H]12
Structure:
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