Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300808
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
15.0±n/a nM
Citation
 Liang, Y; Demarest, KT GPR40 agonists in anti-diabetic drug combinations US Patent  US10195178 Publication Date 2/5/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300808
Synonyms:
(3S)-3-[4-[[3-[4-(1,1-Dioxo-3,6- dihydro-2H-thiopyran-4-yl)-2- methyl- phenyl]benzo[b]thiophen-5- yl]methoxy]phenyl] hex-4-ynoic acid | US10131648, Compound 6 | US10195178, Compound 6 | US9790198, Compound 6
Type:
Small organic molecule
Emp. Form.:
C33H30O5S2
Mol. Mass.:
570.718
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C4=CCS(=O)(=O)CC4)c3c2)cc1 |r,t:29|
Structure:
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