Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300811
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
17.0±n/a nM
Citation
 Liang, Y; Demarest, KT GPR40 agonists in anti-diabetic drug combinations US Patent  US10195178 Publication Date 2/5/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300811
Synonyms:
(3S)-3-[4-[[3-[4-(1,1- Dioxothian-4-yl)oxy-2-methyl- phenyl]-2-methyl- benzo[b]thiophen-5- yl]methoxy]phenyl] hex-4-ynoic acid | US10131648, Compound 9 | US10195178, Compound 9 | US9790198, Compound 9
Type:
Small organic molecule
Emp. Form.:
C34H34O6S2
Mol. Mass.:
602.76
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3sc(C)c(-c4ccc(OC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1 |r,wD:3.7,(8.94,-3.65,;8.55,-2.17,;8.15,-.68,;7.75,.81,;8.84,1.9,;10.33,1.5,;11.41,2.59,;10.72,.01,;6.26,1.21,;5.17,.12,;3.68,.52,;3.29,2,;1.8,2.4,;1.4,3.89,;-.09,4.29,;-.56,5.75,;-2.07,6.07,;-3.1,4.93,;-4.64,4.93,;-5.12,3.46,;-6.45,2.69,;-3.87,2.56,;-4.27,1.07,;-5.76,.67,;-6.15,-.81,;-5.07,-1.9,;-5.46,-3.39,;-6.95,-3.79,;-8.04,-2.7,;-9.53,-3.1,;-9.93,-4.59,;-11.41,-4.19,;-10.33,-6.07,;-8.84,-5.68,;-7.35,-5.28,;-3.58,-1.5,;-3.18,-.02,;-1.69,.38,;-2.62,3.46,;-1.12,3.14,;4.38,3.09,;5.86,2.69,)|
Structure:
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