Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300831
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
34.0±n/a nM
Citation
 Liang, Y; Demarest, KT GPR40 agonists in anti-diabetic drug combinations US Patent  US10195178 Publication Date 2/5/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300831
Synonyms:
2-(1-(4-((3-(4-(1,1- Dioxidotetrahydro-2H- thiopyran-4-yl)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)-3- oxocyclobutyl)acetic acid | US10131648, Compound 29 | US10195178, Compound 29 | US9790198, Compound 29
Type:
Small organic molecule
Emp. Form.:
C33H32O6S2
Mol. Mass.:
588.734
SMILES:
Cc1cc(ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12)C1CCS(=O)(=O)CC1
Structure:
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