Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300858
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
34.0±n/a nM
Citation
 Liang, Y; Demarest, KT GPR40 agonists in anti-diabetic drug combinations US Patent  US10195178 Publication Date 2/5/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300858
Synonyms:
(3S)-3-(4-[[(3-[2-Methyl-4-[(3- methyloxetan-3- yl)methoxy]phenyl]-1- benzothiophen-5- yl)oxy]methyl]phenyl) hex-4-ynoic acid | US10131648, Compound 56 | US10195178, Compound 56 | US9790198, Compound 56
Type:
Small organic molecule
Emp. Form.:
C33H32O5S
Mol. Mass.:
540.669
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCC5(C)COC5)cc4C)c3c2)cc1 |r|
Structure:
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