Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300882
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
20.0±n/a nM
Citation
 Liang, Y; Demarest, KT GPR40 agonists in anti-diabetic drug combinations US Patent  US10195178 Publication Date 2/5/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300882
Synonyms:
(3S)-3-(4-((3-(6-Methoxy-2- methylpyridin-3- yl)benzo[b]thiophen-5- yl)methoxy)phenyl)hex-4-ynoic acid | US10131648, Compound 80 | US10195178, Compound 80 | US9790198, Compound 80
Type:
Small organic molecule
Emp. Form.:
C28H25NO4S
Mol. Mass.:
471.567
SMILES:
COc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)cc23)c(C)n1 |r|
Structure:
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