Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 2
Ligand
BDBM12419
Substrate
BDBM12196
Meas. Tech.
DPP Inhibition Measurements
IC50
90000±n/a nM
Citation
 Van der Veken, P; Senten, K; Kertesz, I; De Meester, I; Lambeir, AM; Maes, MB; Scharpe, S; Haemers, A; Augustyns, K Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases. J Med Chem 48:1768-80 (2005) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
  
Inhibitor
Name:
BDBM12419
Synonyms:
9.7a | Fluoro-Olefin Analogue 1 | N-(2-Cyclopentylidene-2-fluoroethyl)cyclohexan-amine | N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine
Type:
Small organic molecule
Emp. Form.:
C13H22FN
Mol. Mass.:
211.3189
SMILES:
F\[#6](-[#6]-[#7]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)=[#6]-1/[#6]-[#6]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM12196
Synonyms:
2,6-diamino-N-{1-[(4-nitrophenyl)carbamoyl]ethyl}hexanamide | Lys-Ala-p-nitroaniline | Lys-Ala-pNA
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: