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Target
Proteasome subunit alpha type-6
Ligand
BDBM50002338
Substrate
n/a
Meas. Tech.
Proteasome Activity Assay
pH
7.5±n/a
Temperature
310.15±n/a K
EC50
12000±0.0 nM
Comments
extracted
Citation
 Jones, CL; Njomen, E; Sjögren, B; Dexheimer, TS; Tepe, JJ Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins. ACS Chem Biol 12:2240-2247 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit alpha type-6
Synonyms:
27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:
PROTEIN
Mol. Mass.:
27399.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
  
Inhibitor
Name:
BDBM50002338
Synonyms:
(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine) | CHEMBL479 | MELLARIL | MELLARIL-S | THIORIDAZINE | TP-21 | US9504692, Thioridazine
Type:
Small organic molecule
Emp. Form.:
C21H26N2S2
Mol. Mass.:
370.575
SMILES:
CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Structure:
Search PDB for entries with ligand similarity: