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Target
G-protein coupled receptor 183
Ligand
BDBM332559
Substrate
n/a
Meas. Tech.
Cell-Based Luminescent Assay
IC50
12.5±n/a nM
Citation
 Pinkerton, AB; Ardecky, R; Sergienko, EA; Gonzalez-Lopez, M; Ganji, SR; Zou, J Spirocyclic EBI2 modulators US Patent  US10196369 Publication Date 2/5/2019 
Target
Name:
G-protein coupled receptor 183
Synonyms:
EBI2 | GP183_HUMAN | GPR183
Type:
PROTEIN
Mol. Mass.:
41245.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108311
Residue:
361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
  
Inhibitor
Name:
BDBM332559
Synonyms:
5-chloroindol-2-yl 2-{[3-fluoro-4-(trifluoromethyl)phenyl]methyl}-2,7-diazaspiro[3.5]non-7-ylketone | US10196369, Compound C14
Type:
Small organic molecule
Emp. Form.:
C24H22ClF4N3O
Mol. Mass.:
479.898
SMILES:
Fc1cc(CN2CC3(C2)CCN(CC3)C(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(F)(F)F
Structure:
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