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TargetG-protein coupled receptor 183
LigandBDBM332570
Substrate/Competitorn/a
Meas. Tech.Cell-Based Luminescent Assay
IC50 12.5±n/a nM
Citation Pinkerton, ABArdecky, RSergienko, EAGonzalez-Lopez, MGanji, SRZou, J Spirocyclic EBI2 modulators US Patent US10196369 Publication Date 2/5/2019
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 183
Name:G-protein coupled receptor 183
Synonyms:EBI2
Type:PROTEIN
Mol. Mass.:41245.79
Organism:Homo sapiens (Human)
Description:ChEMBL_108311
Residue:361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K
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  Blast E-value cutoff:
BDBM332570
NameBDBM332570
Synonyms:(2E)-3-(4-bromophenyl)-1-{7-[(4-fluorophenyl)methyl]-2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one | US10196369, Compound C25
TypeSmall organic molecule
Emp. Form.C23H24BrFN2O
Mol. Mass.443.352
SMILESFc1ccc(CN2CCC3(CN(C3)C(=O)\C=C\c3ccc(Br)cc3)CC2)cc1
Structure
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n/a