Reaction Details Report a problem with these data
Target
G-protein coupled receptor 183
Ligand
BDBM332583
Substrate
n/a
Meas. Tech.
Cell-Based Luminescent Assay
IC50
12.5±n/a nM
Citation
 Pinkerton, AB; Ardecky, R; Sergienko, EA; Gonzalez-Lopez, M; Ganji, SR; Zou, J Spirocyclic EBI2 modulators US Patent  US10196369 Publication Date 2/5/2019 
Target
Name:
G-protein coupled receptor 183
Synonyms:
EBI2 | GP183_HUMAN | GPR183
Type:
PROTEIN
Mol. Mass.:
41245.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108311
Residue:
361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
  
Inhibitor
Name:
BDBM332583
Synonyms:
5-chloroindol-2-yl 7-[(4-fluorophenyl)carbonyl]-2,7-diazaspiro[3.5]non-2-yl ketone | US10196369, Compound C38
Type:
Small organic molecule
Emp. Form.:
C23H21ClFN3O2
Mol. Mass.:
425.883
SMILES:
Fc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
Structure:
Search PDB for entries with ligand similarity: