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TargetG-protein coupled receptor 183
LigandBDBM332635
Substrate/Competitorn/a
Meas. Tech.Cell-Based Luminescent Assay
IC50 12.5±n/a nM
Citation Pinkerton, ABArdecky, RSergienko, EAGonzalez-Lopez, MGanji, SRZou, J Spirocyclic EBI2 modulators US Patent US10196369 Publication Date 2/5/2019
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 183
Name:G-protein coupled receptor 183
Synonyms:EBI2
Type:PROTEIN
Mol. Mass.:41245.79
Organism:Homo sapiens (Human)
Description:ChEMBL_108311
Residue:361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K
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BDBM332635
NameBDBM332635
Synonyms:3-(4-fluorophenyl)-1-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-2,7-diazaspiro[3.5]non-7-yl)prop-2-yn-1-one | US10196369, Compound C90
TypeSmall organic molecule
Emp. Form.C24H21F5N2O
Mol. Mass.448.4284
SMILESFc1ccc(cc1)C#CC(=O)N1CCC2(CN(Cc3ccc(F)cc3C(F)(F)F)C2)CC1
Structure
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n/a