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Target
G-protein coupled receptor 183
Ligand
BDBM332636
Substrate
n/a
Meas. Tech.
Cell-Based Luminescent Assay
IC50
<5±n/a nM
Citation
 Pinkerton, AB; Ardecky, R; Sergienko, EA; Gonzalez-Lopez, M; Ganji, SR; Zou, J Spirocyclic EBI2 modulators US Patent  US10196369 Publication Date 2/5/2019 
Target
Name:
G-protein coupled receptor 183
Synonyms:
EBI2 | GP183_HUMAN | GPR183
Type:
PROTEIN
Mol. Mass.:
41245.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108311
Residue:
361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
  
Inhibitor
Name:
BDBM332636
Synonyms:
3-(4-chlorophenyl)-1-{7-[(4-methoxyphenyl)carbonyl]-2,7-diazaspiro[3.5]non-2-yl}prop-2-yn-1-one | US10196369, Compound C91
Type:
Small organic molecule
Emp. Form.:
C24H23ClN2O3
Mol. Mass.:
422.904
SMILES:
COc1ccc(cc1)C(=O)N1CCC2(CN(C2)C(=O)C#Cc2ccc(Cl)cc2)CC1
Structure:
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