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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM332759
Substrate
n/a
Meas. Tech.
Antagonism of Humanized OX1 Receptor Assay
IC50
543±n/a nM
Citation
 Zhang, Y; Jin, C; Gao, J; Zhang, J Substituted quinazoline compounds and preparation and uses thereof US Patent  US10196383 Publication Date 2/5/2019 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM332759
Synonyms:
US10196383, Example 2
Type:
Small organic molecule
Emp. Form.:
C24H24FN7O2
Mol. Mass.:
461.4915
SMILES:
CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(F)cc2c(=O)[nH]1
Structure:
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