Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM332758
Substrate
n/a
Meas. Tech.
Antagonism of Humanized OX2 Receptor Assay
IC50
300±n/a nM
Citation
 Zhang, Y; Jin, C; Gao, J; Zhang, J Substituted quinazoline compounds and preparation and uses thereof US Patent  US10196383 Publication Date 2/5/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM332758
Synonyms:
US10196383, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H22FN7O2
Mol. Mass.:
447.4649
SMILES:
Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(F)cc2c(=O)[nH]1)-n1nccn1
Structure:
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